Trends in Philippine Biotechnology

By Dr. Eufemio T. Rasco Jr.

THE country has been committed to promote modern biotechnology for the benefit of its 90 million or so citizens for the last decade or so and it has been slowly but surely working to redeem that vow and make the Philippines a major player in biotech research and development.

For the record, the Arroyo administration has decreed the annual biotechnology week to be celebrated every November and it has set into motion the strict biosafety standards and various protocols covering the development of agricultural biotechnology products. Moreover, the Department of Agriculture

(DA) pushed the development of Bacillus thuringiensis (Bt) corn and herbicide resistant corn expanded production areas from a measly 100 hectares in 2003 to 400,000 hectares last year.

No such genetically modified (GM) crop has enjoyed as much acceptance as Bt corn and does not much require much of herbicides or insecticides. These developments augur well for agricultural biotechnology, which is considered by no less than Agriculture Secretary Arthur C. Yap as a boon to farmers and other indirect workers since it would increase their incomes and provide the livestock industry with alternatives to imported feeds.

The strict standards set by National Committee on Biosafety has made it possible for Filipino scientists to know precisely how they would go about the business of improving the quality and genetic make-up of various crops without any considerable risks to humans and the environment.

Modern biotechnology covers the processes involved in developing better quality crops and animals, more durable agricultural commodities and improved output. These developments are a great leap from traditional biotechnology, which covers fermentation that led to the production of wine more than 6,000 years ago. Microorganisms were the first biotechnology workhorses.

Traditional biotechnology is still being applied universally, from food production to processing, biomedical products like medicines and vaccines and in industry, where cleaning agents are in demand.

Successes in laboratory work and theoretical scientific ventures have made it possible to open new avenues for biotechnology, ranging from gene splicing or genetic engineering, the use of protoplast fusion, the application of DNA markers in establishing paternity, solving crimes, diagnosing diseases, plant breeding, studying evolution and the application of high-technology means as organ and tissue culture.

On the whole, the country is still most comfortable with traditional biotechnology, with their applications seen day-to-day and modern biotechnology still limited to the development of cash crops like corn, cotton, soybeans and canola.

Similarly, biotechnology applications in the biomedical field only cover 25 percent of the total value of medicines. Currently, the Philippines is also trying to work assiduously in bioenergy, with government itself engaged in promoting the development of biofuel feedstock from corn, sugarcane, coconut, jatropha, sorghum, cassava and others.

The law that required rising ethanol content in petroleum products was a good development for the biofuel market as it showed the country is serious in reducing the use of fossil fuels that are being depleted at an alarming rate.

In the next three years, a number of GM crops and fruits are being lined up for commercial release, with the papaya ringspot virus-resistant GM papaya as the first to be propagated.

Apart from papaya, which has enormous possibilities for the natural ingredients market, work is being undertaken for abaca, cotton and others.

GM papaya will have a longer shelf life even as genetic research is being undertaken to develop a strain that would resist diseases that normally decimate nearly half of the papaya grown in larger farms.

The private sector is also doing some work on biotechnology, particularly on multiple stacked genes in corn.

As far as the University of the Philippines-Mindanao (UPMin) is concerned, our work is concentrated on the micropropagation of neglected crops like sago and pitcher plant, the production of biofertilizer from rhizobacteria found in sago, and DNA markers for the Philippine eagle, banana and durian, as well as the industrial processing of sago to produce starch and alcohol.

UPMin has also been involved in testing GM corn since 2003, when its propagation in the country was approved. The university is working on developing new biotechnological process using neglected materials in bid to generate knowledge and deepen our understanding and practice of genetic engineering.

Nepenthes holds promise not only as an ornamental but as a unique “plant-animal hybrid” that can be a potential as a platform for genetic engineering. It is an endangered species endemic to the Philippines.

Thus far, UPMin has made headway in seed propagation, hydropriming and understanding the biology of flowering and seed cultivation, in vitro cutting propagation, plant growing media, acclimatization, and the selling of in vitro seedlings and clones.

In the near future, UPMin believes it can develop the industrial scale propagation and use of the pitcher plant and sago, then later on nipa and Caryota. Work is still at the exploratory stage with funding commitment from the Commission on Higher Education even as full-blown research is starting this year.

The university is involved in tissue culture as even as it continues to breed Nepenthes and supplies commercial nursery operators. These nurseries, in turn, provide end users with nepenthes. Elsewhere in the country, biotechnologists from UP and other universities have been undertaking work on deriving biofuels from aquatic resources, while others have started finding cosmetic applications from marine products, with some scientists actually producing some items for sale in the market.

Rice straws and other organic materials like wood are also being analyzed to determine if they can be viable sources of biofuel and initial results are encouraging. Originally undertaken in the US, work on this field is being done here.

It is not really far-fetched to think that anything green can produce fuel and the earlier we plunge into serious work in this regard, the better chances we have to craft a feasible and viable renewable energy sources.

Many of our colleagues also pay attention to current concerns about the role of agricultural biotechnology products in enhancing environmental integrity, reducing global warming and reversing climate change in the long haul.

Dr. Saturnina C. Halos has dwelled on the positive impact of biotechnology in this direction. She is the chairperson of the Department of Agriculture-Biotechnology Advisory Team (DA-BAT).

Dr. Calixto M. Protacio of the Crop Science Cluster of the University of the Philippines Los Baños (UPLB) has written about the possibility of increasing the lauric acid content of coconuts following the development of GM canola using a gene from the California bay tree and another gene from coconut to increase such content in rapeseed. Due to this breakthrough, rapeseed produces 60 percent lauric acid from zero, posing a threat to coconut oil that is firmly in control of 2 percent to 3 percent of the oil and fatty acids market. By increasing the lauric acid content of coconut oil, it is expected to make a rebound and regain its market share.

Halos says GM crops offer a positive contribution to environmental defense, and quoting reports from the International Service for the Acquisition of Agribiotech Applications (ISAAA), adds: “Reducing pesticide use is simplified with farmers planting purposely designed GM crops. Bt crops, for example, were purposely developed to avoid the application of too much insecticides whereas herbicide-tolerant crops to avoid the use of a cocktail of chemical herbicides. The success of this option is borne by the recent finding that use of pesticides has been reduced by 286 million kilos in the 10 years (1996-2006) that GM crops have been planted with a 15.4 percent reduction in the environmental impact associated with insecticide and herbicide use. Over half of the environmental benefits associated with lower insecticide and herbicide use has been in developing countries (52 percent). A corresponding decrease in carbon emission reduction has been found.

GM crops contribute to a reduction in fuel use due to less-frequent herbicide or insecticide applications and a reduction in the energy use in soil cultivation. Reduced soil cultivation is associated with herbicide tolerant crops.”

ISAAA also reported that three years ago, the permanent carbon dioxide savings from reduced fuel use associated with GM crops was 1.2 billion kilos globally. It is like removing 540,000 cars from the road for a year, she adds.

We look forward to seeing the steady advance of biotechnology research and development (R&D) as the country strives to increase agricultural output and raise the incomes of farmers.

In the end, whatever we do to boost our biotechnological progress should redound to better lives for millions of our fellow citizens. By achieving this, we shall have given the nation a big bonus.

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Trends in Philippine Biotechnology

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